The aim of the post is to provide research support in bioinformatics for the BBSRC/EPSRC Synthetic Biology Research Centre (SBRC). SBRC Nottingham is one of six UK centres created by the BBSRC/EPSRC. It originally received grant funding of £14.3M and has just received extension funding of £3m.
The centre is primarily focused on the exploitation of bacterial chassis for the sustainable production of chemicals and fuels through carbon recycling.
This involves the characterisation and engineering of a diverse range of microbes, from mesophiles to thermophiles, aerobes to anaerobes, Gram-negative to Gram-positive as well as heterotrophs to autotrophs. The SBRC also has a programme of work concerned with the development of effective countermeasures against clostridial pathogens.
The role will be to provide bioinformatics support using available software packages (commercial and open access) to underpin the processing, analysis and visualisation of genomic data arising from engineered and wildtype strains through a combination of directed and random approaches.
This will include the identification and characterisation of mutations in rationally altered as well as evolved strains using high throughput nucleotide sequencing, transcriptomic and methylome data (PacBio, Illumina and Nano-pore). Aspects to be investigated include countering endogenous Restriction/Modification and CRISPR systems and maximising the impact of data emerging from Transposon-directed Insertion Sequencing (TraDIS) analysis of the various SBRC chassis under various niche specific conditions.
The post will operate within a framework of Responsible Research Innovation (RRI) under the guidance of SBRC social scientists and be expected to undertake outreach activities coordinated by the SBRC Outreach Officer. The role holder will have the opportunity to use their initiative and creativity to identify areas for research, develop research methods and extend their research portfolio.
Candidates must hold a PhD (pending or awarded) or equivalent in a discipline relevant to Bioinformatics.
This full-time (36.25 hours per week), fixed-term post is available as soon as possible until 31 March 2021. Job share arrangements may be considered.
Informal enquiries may be addressed to Professor Nigel Minton: firstname.lastname@example.org Please note that applications sent directly to this Email address will not be accepted.
The School of Life Sciences holds an Athena Silver SWAN Award, in recognition of our commitment to supporting and advancing women’s careers in the life sciences (STEMM). You can read more about this initiative at http://www.nottingham.ac.uk/life-sciences/documents/athena-swan-silver-award.pdf
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