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Senior Scientist (Chemistry) On Market Technical, Chemical Development

43,084 P.A. ?

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At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Every single day, we make a difference by delivering potentially life-changing medicines to millions of people globally and by leading breakthrough science that promises to transform the treatment of disease. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency. We are curious, creative, and open to new ideas and ways of working.

At AstraZeneca, we believe in the potential of our people and you’ll develop beyond what you thought possible! We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

Pharmaceutical Technology and Development (PT&D) are the bridge, which turns forward-thinking science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Drug Substance On-Market Technical

In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients (API) of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.

We now have an exciting opportunity for a Senior Scientist in our growing On-Market Technical group within Chemical Development. The group is dedicated to the lifecycle management of commercial API at AstraZeneca. The drivers are to maintain continuity of supply, ensure license to operate and continue to deliver business value through optimisation of manufacturing processes and supply chain design. AstraZeneca currently manufactures a high percentage of API externally at Contract Manufacturing Organisations (CMOs).

What you'll do

As an experienced chemist you will provide technical contribution to project teams to ensure we maintain and optimise supply for AstraZeneca commercial products meeting cost and quality targets for our customers. This includes:

  • Provision of scientific input to assessment of change, deviation assessment and process and manufacturing improvements
  • Contribution to the CMC components of regulatory submissions
  • Preparation of successful query responses over the commercial lifecycle
  • Technology Transfer of processes to CMOs
  • Identifying and driving process improvements
  • Ensuring delivery of SHE and cGMP compliance, with all work carried out to AstraZeneca and external regulatory policies and standards
  • Enhancing the reputation of the company in scientific circles by representing AstraZeneca, through external presentations, publications, membership of working parties and through academic collaborations

All of these activities will have a vast impact on the speed, quality and cost of the AZ commercial portfolio, the overall success of the Supply Chain, as well as ensuring the commercial viability of the medicine. The role, therefore, has a significant impact on both financial and reputational aspects of the business.

Essential Requirements:
  • A PhD in Organic Chemistry, or BSc/MSc with relevant industrial experience to an equivalent level
  • Substantial experience in practical organic synthesis
  • An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques
  • Understanding of scale up operations
  • The ability to think innovatively to drive improvement, and address issues when contributing to project strategies
Desirable Requirements:
  • Experience of working within a Research & Development and Manufacturing environment, within the pharmaceutical industry
  • The ability to develop and analyse multiple solutions to problems
  • The confidence to coach and drive performance and development among your peers
Skills and capabilities:
  • Ability to challenge and innovate, bringing new solutions and opportunities for chemical development
  • Proven problem solver with in depth technical skills
  • Excellent communication skills, able to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally
  • The ability to confidently participate in, and potentially lead, improvement projects

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering ground-breaking methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Full time

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