The Systems Modeling and Translational Biology (SMTB) department is seeking a Quantitative Systems Pharmacology/Toxicology scientist passionate about using advanced mathematical modeling and computational sciences to develop and use mechanistic models of disease processes (QSP) and toxicology (QST).
The SMTB group uses mathematical modeling and simulation to address the relationships between drug properties, its disposition and the pharmacological and toxicological response to translate from in-vitro and in-vivo preclinical species to humans. This involves the integration and interpretation of data from many sources to help drive project decisions.
Working in a dynamic, multidisciplinary environment the successful candidate will develop, calibrate and use large scale Quantitative Systems Pharmacology/Toxicology models combined with drug pharmacokinetics to link mechanistic drug disposition with target biology and clinical outcomes for various diseases. In particular, experience with PBPK models for large molecule therapeutics is preferred.
This position is an exciting opportunity to make a difference in the lives of patients by applying mechanism based mathematical modeling coupled with biological knowledge to drive drug discovery and development. The level for this position is flexible and will depend on the qualifications of the selected candidate.
• Develop QSP/QST models and apply them to impact the progression of drug discovery and development programs
• Responsible for providing modeling support to assigned therapeutic and toxicity areas
• Develop and execute a modeling strategy for assigned therapeutic area ensuring availability of appropriate modeling support
• Peer review modeling work from colleagues as appropriate, insuring high quality standards for the modeling work
• Build, expand and refine the modeling capabilities and software platforms of SMTB
• Provide consultancy and training resource to increase the overall kinetic thinking and modeling capability of staff across R&D
• Exceptional collaborative behaviors to build and maintain relationships with R&D therapy area scientists as well as the wider modeling community in GSK
• Promote and increase the reputation of the modeling internally within R&D and externally including regulatory agencies
We are looking for professionals with these required skills to achieve our goals:
If you have the following characteristics, it would be a plus:
Our values and expectationsare at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
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