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MSc or PHD Medical Statistics student intern

Location: Uxbridge
Company: Bristol-Myers Squibb
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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The intern position is open to candidates currently studying for their MSc or PHD in medical statistics, with the position lasting between 3 and 6 months depending on whether the applicant is full-time or part-time studying and their university course.
Pediatric studies and small sample size
In recent times, the needs for new drugs to be tested within the pediatric setting has increased to now being an integral requirement of the regulatory process, with legislation surrounding pediatric drug testing undergoing many changes in recent time; more recently the FDA Reauthorization Act (FDARA 504), enacted August 2018 and took effect August 2020.
With ever increasing needs for pediatric studies, so to has the need to increase clinical trial methodologies in terms of when to plan and develop, clinical trial design and how to maximize data use in the unique and challenging setting where data is limited and available subjects spare.
Most pediatric studies in hematology/oncology inherently rely on the availability of subjects from a small population, resulting in unique challengers such as study design, and leveraging the most from the available study data. In a setting where subject availability is low and sometimes in a competitive clinical trial setting with ever increasing robust results requires, there is high value for advancement of statistical methodologies are outlined.
BMS is now in the process of developing a Pediatric Centre of Excellence, creating a knowledge center which will bring people from across all functions with a focus to advancing pediatric drug development. Having an intern that may in some part be able to help shape future thinking will be a welcome addition. The Pediatric Center of Excellence Mission: To fulfill regulatory requirements and exclusivity needs and advance the development of medicines that help pediatric patients prevail over disease.
Exploring various clinical trial designs using small sample sizes in various phase 2 settings, and the best use of a control arm will be integral parts to this internship. Using completed Celgene/BMS pediatric studies to work off of, simulation techniques should be applied to help understand and identify the most appropriate type(s) of study designs and how best to incorporate a comparison of the experimental arm to a control, be it a form of randomized arm, historical control arm, or a simulated arm based on literature reviews. In short; how to optimize the available study population and the data it has to offer as well as data readily available in the literature.
Resampling methods (i.e. bootstrapping, jackknifing, and hot-decking) may also be considered, to further identify the most appropriate methodology under various simulations, in the phase 2 study setting when considering different types of endpoints and how the endpoints are analyzed.
Skills/Knowledge Required (technical and soft skills)
- Master student in Statistics (ideally Medical Statistics / Biostatistics) with good understanding of basic methodology of clinical research.
- Good working knowledge of using SAS (and/or R) and MS Office products (Word, PowerPoint)
- Be able to work well in a team and independently.
- Good organization and communication skill
Benefits to the candidate
- The candidate will become more familiar with the drug development process with regards to study designs and the topics included in this proposal, as well as regulatory requirements.
- Internship should be considered part of the student education and the work contribute partly/fully to their MSc thesis.
- Internship outcomes may lead to publications and further researches.
- Additional benefits for the chosen student is they would develop a good footing for a future career within the pharmaceutical industry, and learning and understanding requirements of them and of the industry as well as a sense of achievement, pride, responsibility gained and working within a global company both in a team and independently.
Other relevant items *:
The duration of the intern position will range between 3 and 6 months depending on whether the candidate is a part-time or full-time student.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognises the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. If you require reasonable adjustments in completing this application, or any part of the recruitment process direct your enquiries to Applicants can request an approval of an adjustment prior to accepting a job offer.
Company: Bristol Myers Squibb
Req Number: R1544038
Updated: 2021-10-18 01:00:20.418 UTC
Location: Uxbridge,United Kingdom
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
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